Pharmacokinetic and pharmacodynamic evaluation of classical psychedelic substances in the human brain

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Abstract
One of the prominent theories of the action of psychedelic drugs on the brain is the so-called entropic brain hypothesis which posits that the acute effects of psychedelics are a reflection of increases in the chaotic or entropic nature of brain activity. This has largely been tested using functional MRI data which measures blood oxygenation, a proxy for neural activity. So far, twelve papers have evaluated fMRI measured brain entropy, but each has used a distinct means of calculating entropy in a single pre vs post drug design. In our study we expand upon the previous research by evaluating all twelve of the previously used metrics in a multiple post-drug scan design.

Bio
Drummond McCulloch works at the Neurobiological Research Unit Rigshospitalet, Copenhagen University Hospital.
He has a background in drug design and pharmacology, and now works as a PhD Fellow at the Neurobiology Research Unit, Copenhagen, where he is supervised by Professors Patrick Fisher and Gitte Moos Knudsen. There, Drummond coordinates clinical trials using fMRI, EEG and PET to evaluate the acute and persisting effects of psilocybin and LSD on the brain.

E-mail
[email protected]

More information
https://nru.dk/…/phd-students/273-drummond-mcculloch

When

April 12, 2023    
7:00 pm - 9:00 pm

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Where

CREA Amsterdam
Nieuwe Achtergracht 170, Amsterdam

Event Type

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