The journal club discussion will take place in CREA on Wednesday, June 18th from 19.00 to 20.00. Following the discussion, we’ll have a community meetup downstairs in the CREA cafe starting at 20.00! Can’t make it to the journal club? You’re still very welcome to join afterwards for drinks!
Abstract
The psychedelic compound psilocybin has recently emerged as a therapeutic intervention for various mental health conditions. Psilocybin is a potent agonist of serotonin (5-HT) receptors (5-HTRs), which are expressed in the brain and throughout peripheral tissues, with particularly high expression in the gastrointestinal (GI) tract. However, no studies have investigated the possibility that peripheral actions of psilocybin may contribute to improvements in mental health outcomes. This is despite strong evidence for disturbed gut-brain signalling in conditions in which psilocybin is being tested clinically. In this Opinion, we highlight the likely actions of psychedelics in the gut and provide initial support for the premise that peripheral actions may be involved in rapid and long-term therapeutic effects. A greater understanding of all sites and modes of action will guide more targeted approaches to drug development.
Why attend a Journal Club?
During Journal Clubs we discuss scientific publications related to psychedelics, dissect their contents and have an in-depth discussion about the methodology and implications of the research. Not only is it very insightful (and fun!) to do this in group form; it also helps improve your literacy of scientific publications. All levels of knowledge are welcome. You do not need to be an expert in the topics that are discussed – “no stupid questions” is the motto!
Location
Entry
Bookings
Bookings are closed for this event.