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Journal Club #11 - Koen Seignette (PhD cand.): "Feedback-feedforward information processing unbalances and the neurophysiology of hallucinations"

21/5/19, Vrije Universiteit Amsterdam


1 min

Our 11th JC installment will be hosted by Koen Seignette, PhD student at the Netherlands Institute for Neuroscience. Koen's work focuses on sensory processing and plasticity, perceptual learning, feedforward and feedback integration in mouse V1, in the Christiaan Levelt Lab.

Where: Vrije Universiteit Amsterdam, Medical Faculty Building, Room D565
When: Tuesday, May 21st, 6pm (presentation will start ~6.15pm)
RSVP: Facebook Event

Entrance is free for APRA members who have paid the current year membership fee, a small donation is suggested for non-members (5 euro).


Perceptual disturbances in psychosis such as hallucinations have been associated with an imbalance in the information streams in the sensory cortex. That is a disruption between the processing of sensory information and signals from higher brain areas like the prefrontal cortex.

In this Journal Club, I will first outline the hypothesis and introduce key concepts of feedforward and feedback information processing. I will then discuss two recent papers [1, 2] that attempt to test this hypothesis in sensory cortex of awake mice.



[1] Ranson, Adam, et al. "Top-Down Suppression of Sensory Cortex in an NMDAR Hypofunction Model of Psychosis." Schizophrenia bulletin (2019).

[2] Michaiel, Angie M., et al. "A Hallucinogenic Serotonin-2A Receptor Agonist Reduces Visual Response Gain and Alters Temporal Dynamics in Mouse V1." Cell reports 26.13 (2019).